Points standingP W D L GF GA GD Pts1. Arsenal 21 13 4 4 37 21 16 432. Leicester 21 12 7 2 38 25 13 433. Man City 21 12 4 5 39 21 18 404. Tottenham 21 9 9 3 34 17 17 365. West Ham 21 9 8 4 33 24 9 356. Man United 21 9 7 5 27 20 7 347. Stoke City 21 9 5 7 24 22 2 328. Crystal Palace 21 9 4 8 23 20 3 319. Liverpool 21 8 7 6 25 27 -2 3110. Watford 21 8 5 8 25 24 1 2911. Everton 21 6 10 5 36 29 7 2812. Southampton 21 7 6 8 28 24 4 2713. West Brom 21 7 6 8 22 27 -5 2714. Chelsea 21 6 6 9 28 31 -3 2415 Norwich City 21 6 5 10 24 35 -11 2316. Bournemouth 21 5 6 10 23 37 -14 2117. Swansea City 21 4 7 10 19 30 -11 1918. Sunderland 21 5 3 13 26 41 -15 1819. Newcastle 21 4 6 11 22 38 -16 1820. Aston Villa 21 2 5 14 17 37 -20 11
June 22, 2002 Paolo Soleri celebrated his eighty-third birthday a day early inthe company of Arcosanti residents. Held over lunchtime frugal soup, the celebration was quiet and thoughtful.[Photo & text: MS] . [Photo & text: MS] Bakeryworker Brandy Follet (left) and manager Valerie Loft (right)surprised Paolo with an elaborate and delicious birthday cake. [Photo &text: MS] >>left>> Valerie presenting her masterpiece to Paolo. >>right>> Paolo>>serving cake to residents [Photo & text : MS].
Categories: Cox News,Cox Photos State Rep. Laura Cox, R-Livonia, is sworn in by Michigan Supreme Court Chief Justice Robert Young Jr. (left). She was joined by (from left) her daughter Sinéad, her husband Mike, and her parents Robert and Peggy Erpelding. 15Jan Rep. Cox sworn in for first term
The EBU’s technology and innovation director Lieven Vermaele is to leave the organization to return to his native Belgium and take on the role of CEO of a technology startup.The EBU has announced that it is recruiting a replacement for Vermaele. The technology director reports to the EBU’s director-general and sites on the organisation’s management committee.
Reviewed by Alina Shrourou, B.Sc. (Editor)Oct 7 2018Leadiant Biosciences, Inc. today announced that the Food and Drug Administration (FDA) has granted approval to Revcovi™ (elapegademase-lvlr) injection in the U.S. Revcovi is a new enzyme replacement therapy (ERT) for the treatment of adenosine deaminase severe combined immune deficiency (ADA-SCID) in pediatric and adult patients.”We are gratified by the FDA’s timely recognition of Revcovi as an effective and safe treatment for ADA-SCID, which, in addition to being ultra-rare, is one of the most devastating genetic disorders,” said Michael Minarich, Chief Executive Officer, Leadiant Biosciences, Inc. “We extend our deepest gratitude to the patients who participated in the clinical trials and their families and caregivers who supported them. We also appreciate the hard work of the investigators, clinicians, and study staff to bring this therapy to patients in need. We look forward to continuing to work together to serve the ADA-SCID community.”Revcovi is a PEGylated recombinant adenosine deaminase (rADA) enzyme developed by Leadiant Biosciences to treat ADA-SCID. The product of recombinant technology, Revcovi eliminates the need to source the enzyme from animals and works by supplementing levels of an essential enzyme called adenosine deaminase (ADA).ADA-SCID is an ultra-rare, inherited genetic disorder, caused by a deficiency in the ADA enzyme that is fatal if left untreated. Patients affected by ADA-SCID have compromised immune systems that leave them unprotected from infection-producing bacteria, viruses, and fungi. ADA-SCID primarily affects infants and young children. The disease is typically diagnosed within the first few months of life. Undiagnosed babies with ADA-SCID usually die before they reach age two due to infections. SCID newborn screening in most states has allowed detection of ADA-SCID in newborns and has led to early initiation of ADA enzyme therapy and improved outcomes.”For decades, physicians, patients, and their families have relied upon enzyme replacement therapy as a life-saving treatment for adenosine deaminase severe combined immunodeficiency, a disease in which the buildup of toxic metabolites can cripple children’s immune systems,” said Morna Dorsey, M.D., MMSc, Professor of Pediatrics at the University of California, San Francisco. “Individuals with ADA-SCID are at an increased risk of severe and recurrent infections and often fail to thrive. By providing specific and direct replacement of the adenosine deaminase enzyme, Revcovi can reduce patients’ risk of potentially serious, life-threatening infections and their debilitating complications.”Related StoriesScientists discover how resistance to the chemotherapy drug 5-fluorouracil arisesIDT releases new ultra-high performance CRISPR Cas12a enzymeScientists turn type A blood into universal type O, potentially doubling blood transfusion stocksThe approval is based on results from two multicenter, open-label clinical trials which demonstrate that Revcovi increases ADA activity, reduces concentrations of toxic metabolites that are the hallmark of ADA-SCID and improves total lymphocyte counts.”This is a great day for people living with ADA-SCID and their families as the approval of Revcovi gives them a path forward,” commented John Boyle, President and Chief Executive Officer of the Immune Deficiency Foundation. “We commend Leadiant Biosciences for bringing this innovative enzyme replacement therapy to market, and for helping to advance scientific understanding of ADA-SCID.””The competence and dedication of our staff was instrumental to obtain this important achievement for the ADA-SCID community,” said Dr. Marco Brughera, Chief Executive Officer, Leadiant Biosciences Corporate. “With the FDA’s approval of Revcovi, we reaffirm our commitment and rare dedication to providing a reliable supply of quality, innovative therapies that serve the needs of rare disease communities.”Leadiant is working with physicians, payers, and policymakers to bring Revcovi to patients who need it. The Company offers comprehensive treatment support, from educating about the disease, to navigating reimbursement, to offering patient assistance programs. The Company’s post-marketing commitment includes a clinical study, which will record information about the health status of patients using Revcovi. This initiative will help Leadiant better understand and track information about Revcovi following approval as well as provide critical information about Revcovi’s efficacy and safety, especially in newly diagnosed patients.Leadiant is a research-based pharmaceutical company that dedicates considerable scientific and financial resources to the research, development, and distribution of novel and effective therapies to address the needs of people living with rare diseases. The Company markets five rare disease products in North America and has been working in the enzyme replacement therapy space for more than 30 years. The Company is committed to serving the needs of patients, caregivers, and families affected by ADA-SCID.The FDA granted this application Fast Track and Priority Review. Revcovi also received Orphan Drug designation. Source:http://leadiantbiosciences.com/
By Sally Robertson, B.Sc.Mar 18 2019New research published by the American Psychological Association has found that the rate of certain mental health disorders has increased significantly over the last decade among young adults, but not among older adults. Lead author of the study, Jean Twenge (San Diego State University), believes the use of digital media and electronic media may be changing how people socially interact and affecting their mood.More U.S. adolescents and young adults in the late 2010s, versus the mid-2000s, experienced serious psychological distress, major depression or suicidal thoughts, as well as more attempted suicide, reports Twenge: “These trends are weak or non-existent among adults 26 years and over, suggesting a generational shift in mood disorders instead of an overall increase across all ages.”Related StoriesInternational study aims to more accurately describe mental health disordersOnline training program helps managers to support employees’ mental health needsBiden calling ACA ‘breakthrough’ for mental health parity highlights gapsAs reported in the Journal of Abnormal Psychology, Twenge and team looked at data from the National Survey on Drug Use and Health, which has monitored drug/alcohol use and mental health among people (aged 12 and older) in the U.S. since 1971.They compared data for more than 200,000 individuals aged 12 to 17 between 2005 and 2017 with data for nearly 400,000 people aged 18 or over between 2008 and 2017.Among the adolescents, the rate of major depression symptoms in the previous year increased by 52% between 2005 and 2017. Among young adults (aged 18 to 25), the rate increased by 63% between 2009 and 2017 and there was also a 71% increase in reports of serious psychological distress in the previous 30 days between 2008 and 2017. Furthermore, the rate of suicidal thoughts or other suicide-related outcomes among young adults increased by 47% between 2008 and 2017.During these same time periods, there were no significant increases in the rates of depression or psychological distress among older adults.”Cultural trends in the last 10 years may have had a larger effect on mood disorders and suicide-related outcomes among younger generations compared with older generations,” says Twenge.She suggests that the increased use of digital media and electronic communication may have affected adolescents and young adults more because older adults have more stable social lives that may have changed less than the social lives of younger people. Older adults may also be less likely to let social media disrupt their sleep by staying up late using their phones, for example.”These results suggest a need for more research to understand how digital communication versus face-to-face social interaction influences mood disorders and suicide-related outcomes and to develop specialized interventions for younger age groups,” concludes Twenge.Source: https://www.eurekalert.org/pub_releases/2019-03/apa-mhi030819.php
Reviewed by James Ives, M.Psych. (Editor)May 8 2019For many people who care for aging parents, one solution is a safe, responsible nursing home.But an increasingly common means of ensuring that safety — security cameras installed by relatives — may do more harm than good, says Clara Berridge, an assistant professor of social work at the University of Washington.With reports of crimes against nursing home residents gaining media attention around the country, it’s understandable that families would want to protect their loved one and attempt to establish accountability for care, Berridge said. But in articles published late last winter in AJOB Empirical Bioethics and Elder Law Journal, Berridge outlines the list of legal and moral issues that surveillance raises.”The use of cameras in resident rooms is so common that some states have passed laws to help families and facilities navigate the legal issues. But it’s not just a gray zone for law. Lots of ethical issues are at play, and it raises the question of privacy’s role in our lives.”At least 10% of Americans ages 60 and older are believed to have been the victim of some form of elder abuse, whether physical, sexual or psychological, or in the form of financial mismanagement or a deprivation of resources such as food or medication. (Cases are believed to be underreported, making the 10 percent figure a low estimate.) While most abuse is committed by relatives, the high-profile nature of crimes against nursing home residents by facility staff can alarm anyone whose loved one is in residential care. This is especially true for families of people with forms of dementia, because those residents are less likely to be able to accurately report abuse.So far, seven states, including Washington, have passed laws allowing placement of surveillance cameras in the rooms of nursing home residents. In the Elder Law Journal article, Berridge and her co-authors analyze each state’s law and conclude that for each law, privacy concerns remain.For the study published in AJOB Empirical Bioethics, Berridge distributed an online survey through the Center for Gerontology and Healthcare Research at Brown University to nursing homes and assisted living facilities. More than 270 facilities from 39 states responded to the anonymous survey, which included specific and open-ended questions about policies and use of surveillance cameras. Of the caregiving facilities that responded, some 11% had initiated use of cameras on their premises.In this survey, the majority of respondents cited privacy and dignity of residents as key disadvantages to cameras.By their very nature, surveillance cameras record all of the activity in a room, including personal moments such as hygiene or dressing. From a crime-prevention perspective, those are times when a resident is most vulnerable, but from a privacy perspective, the resident may not want such footage to be recorded, let alone viewed.Tied to questions about privacy is the issue of consent, Berridge said – not only whether the resident has the capacity to consent to being monitored, but also, in the case of two-person rooms, whether the roommate can consent.Related StoriesResearch reveals the parenting habits of our earliest extinct ancestorsUAMS receives $24.2 million federal funding to accelerate researchStudy examines potential advantages and disadvantages of blister packaging for nursing homes”Most nursing home residents have a roommate. Protecting their privacy when a camera is in the room would be very difficult in practice, especially if the camera picks up audio,” Berridge said. “We found that the real-life constraints on opportunities to selectively move or cover a camera in a given situation are not acknowledged in the state laws. These are chronically understaffed settings.”A less-cited — and often overlooked — issue, Berridge added, is the legal responsibility the camera owner has for the security of the feed. Installing a camera without establishing a secure portal can expose the resident (and a roommate) to hackers.Respondents to the survey pointed to potential advantages of cameras, as well, particularly as deterrents to abuse, and to use by the facilities themselves to inform about individual residents’ needs and as resources to help staff improve.Ultimately, Berridge and her co-authors say that while cameras may offer families some comfort, they aren’t the answer to preventing abuse, or a proxy for accountability. Rather, the focus should be on reform and increased funding for the long-term care system so that nursing homes and assisted living facilities are sufficiently staffed, with employees paid a living wage. Berridge points to a “culture change” movement in long-term care that aims to deinstitutionalize nursing homes and make them more home-like. This movement involves practices to improve care quality, enhance person-centeredness, and empower staff. In Washington, lawmakers this year passed the Long-Term Care Trust Act, which establishes a publicly funded source of long-term care insurance. The measure, which awaits Gov. Jay Inslee’s signature, may help people pay for in-home services as an alternative to nursing home care.Berridge recently received a four-year, nearly $500,000 grant from the National Institute on Aging to develop a self-administered tool to help people with Alzheimer’s disease and other forms of dementia and their families understand and make decisions about the use of a range of technologies that remotely monitor people in their homes for their safety, including webcams. Unlike cameras in nursing home rooms that are aimed at potential abusers, technologies addressed in this study are used to monitor older adults’ activities and behaviors. It’s easy, Berridge explained, for adult children to overlook, or even dismiss, the concerns of a parent when it comes to issues of monitoring care, and the parent’s right to privacy and sense of freedom.”This tool will be the first of its kind to support families to navigate the complex technology landscape and guide them in balancing their perceived need for ongoing surveillance and the older adult’s dignity and wishes,” Berridge said. Source:http://www.washington.edu/news/2019/05/06/security-cameras-in-nursing-homes-aim-to-protect-the-vulnerable-but-present-ethical-dilemmas/